Ergo Plus features the concentrated form of the histone derivative L-ergothioneine produced via a proprietary fermentation-based method. Through its antioxidant and cytoprotectant mechanisms, L-ergothioneine combats oxidative stress throughout the body and provides multiple health benefits.*

In the central nervous system, L-ET crosses the blood–brain barrier and is neuroprotective.2,5 Blood levels of L-ET decline with age, and a faster decline is observed in individuals with mild cognitive impairment.1,2

The results of a cross- sectional study (N = 496) correlated low levels of L-ET with dementia severity and suggested that serum L-ET could be a potential biomarker associated with cognitive impairment. Furthermore, neuroimaging showed that lower L-ET levels were significantly associated with cortical thinning and decreased hippocampal volumes.

In other research, animal study outcomes suggest that L-ET improves stress-related sleep disorders and relieves depressive-like behaviors.11,12

In a 2022 double-blind, randomized clinical trial of individuals (N = 95) with reported high anxiety and sleep complaints, 20 mg/d of ergothioneine for 4 weeks reduced sleep difficulties, including frequency of waking Ergo Plus is a 99% pure, concentrated L-ET ingredient developed via a proprietary fermentation-based method.

This sustainable production method is preferable to chemical synthesis or expensive purification of L-ET from food and results in the stable thione-based L-isomer in free amino acid form.