Ergo Plus features the concentrated form of the histone derivative L-ergothioneine produced via a proprietary fermentation-based method. Through its antioxidant and cytoprotectant mechanisms, L-ergothioneine combats oxidative stress throughout the body and provides multiple health benefits.*
In the central nervous system, L-ET crosses the blood–brain barrier and is neuroprotective.2,5 Blood levels of L-ET decline with age, and a faster decline is observed in individuals with mild cognitive impairment.1,2
The results of a cross- sectional study (N = 496) correlated low levels of L-ET with dementia severity and suggested that serum L-ET could be a potential biomarker associated with cognitive impairment. Furthermore, neuroimaging showed that lower L-ET levels were significantly associated with cortical thinning and decreased hippocampal volumes.
In other research, animal study outcomes suggest that L-ET improves stress-related sleep disorders and relieves depressive-like behaviors.11,12
In a 2022 double-blind, randomized clinical trial of individuals (N = 95) with reported high anxiety and sleep complaints, 20 mg/d of ergothioneine for 4 weeks reduced sleep difficulties, including frequency of waking Ergo Plus is a 99% pure, concentrated L-ET ingredient developed via a proprietary fermentation-based method.
This sustainable production method is preferable to chemical synthesis or expensive purification of L-ET from food and results in the stable thione-based L-isomer in free amino acid form.
Serving Size: 1 Capsule
Servings Per Container: 30
- L-ErgothioneineS1 12.5 mg **
** Daily Value not established.
Other Ingredients: Microcrystalline cellulose, dicalcium phosphate, capsule (hypromellose and water), ascorbyl palmitate, and silica.
Formulated To Exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
Take one capsule once or twice daily, or use as directed by your healthcare professional.
Consult your healthcare professional before use.
Individuals taking medication should discuss potential interactions with their healthcare professional.
Do not use if tamper seal is damaged.